Crohn’s disease, according to the original article, is a condition affecting one in every 800 people in the United Kingdom . The usual symptoms for this disease are chronic intestinal pain, inflammation, pain, diarrhea and bleeding. It is has no known cure at present. The research study mentioned in the article talks about a certain bacteria in cow’s milk that may also cause Crohn’s disease in humans. The pathogenic bacterium called Mycobacterium paratuberculosis, which can be seen using biologic monocular microscopes, is thought to release a molecule which inhibits a type of white blood cell from killing another bacteria called E. coli. An increased number of E. coli exists on the gut or intestinal tissues of humans affected with Crohn’s disease.

Biological monocular microscopes can be used in studying bacteria like the pathogens E. coli and Mycobacterium paratuberculosis. By using biological monocular microscopes, researchers can find out the physiology of a bacterium and how it can infect other specimens. The researchers deduce that the Mycobacteria infect humans thru ingestion of cow’s milk and dairy products. This pathogen also causes Johne’s disease among cattle. Johne’s disease causes cattle to have wasting, chronic diarhea. At present, researchers do not have the answer on how this pathogen could cause intestinal tissue inflammation among humans.

Mycobacterium paratuberculosis is also found among tissues of patients affected with Crohn’s disease but due to the controversy (interspecies infection), no direct connection can be made. The researchers also think that this bacterium is a likely trigger for an antibody protein called ASCA. This protein is found on two thirds of patients affected with Crohn’s disease which may be a link (weak link) on person’s affected with Crohn’s disease could also be affected by this Mycobacteria.

What the researchers know, however, is that this Mycobacteria releases a complex molecule that contains a sugar called mannose. The molecule inhibits macrophages, a type of white blood cell, from destroying E. coli that is internalized. Biologic monocular microscopes can be used in magnifying tissue and cell structures to better study the interactions between these structures and he pathogens infecting it. The more complex the structure is, the higher the magnification is needed to study it. With the use of advanced microscopes, like the biological monocular microscopes, researchers will have an easier task ahead of them in finding the pathophysiology of a disease.

By studying tissue samples of humans affected with Crohn’s disease, researchers have found out, with the use of biological monocular microscopes, that the tissues have increased numbers of E. coli that are of sticky type. The sticky type of E. coli is weak and could not effectively fight off other intestinal bacteria. The researchers hypothesized that due to the Mycobacteria, the human body’s defense against other intestinal bacteria is weakened. Another study, in effect, has been done to make clinical trials for an antibiotic that can prevent and target the specific bacterium that is seen in white blood cells. Using biological monocular microscopes, tests can be done to formulate the best antibiotic that could kill the bacterium. This could be the beginning of a cure for Crohn’s disease. Read more on this subject